Asimetriskās aminokatalīzes pielietojums Hanča sintēzē
Loading...
Date
Authors
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Language
N/A
Abstract
Darbā ir apkopota un analizēta literatūra par asimetriskajām organokatalītiskajām Mihaeļa reakcijām. Veikti kvantu ķīmiskie aprēķini imīnija un amināla katjoniem, kas satur halkona grupējumu. Veikta hirālu imidazolidinona un pirilidīna tipa organokatalizatoru sintēze. Optimizēta metode 1,4-DHP enantiomērās tīrības noteikšanai. Sintezēti halkoni ģeometriski tīrās formās, kā arī veiktas katalītiskās Hanča sintēzes reakcijas
The literature data on asymmetric organocatalytic Michael reactions have been collected and analysed. The quantum chemical calculations of chalcone moiety containing iminium and aminal ion geometry have been done. Chiral imidazolidinone on pyrolidine catalysts have been prepared. 1,4-DHP enantiomeric excess determination method has been optimized. Synthesis of chalcones in geometrically pure have been performed. Catalytic Hantzsch synthesis reactions have been carried out.
The literature data on asymmetric organocatalytic Michael reactions have been collected and analysed. The quantum chemical calculations of chalcone moiety containing iminium and aminal ion geometry have been done. Chiral imidazolidinone on pyrolidine catalysts have been prepared. 1,4-DHP enantiomeric excess determination method has been optimized. Synthesis of chalcones in geometrically pure have been performed. Catalytic Hantzsch synthesis reactions have been carried out.