dc.contributor.advisor | Logins, Jāzeps | en_US |
dc.contributor.author | Leite, Irēna | en_US |
dc.contributor.other | Latvijas Universitāte. Ķīmijas fakultāte | en_US |
dc.date.accessioned | 2015-03-24T07:04:40Z | |
dc.date.available | 2015-03-24T07:04:40Z | |
dc.date.issued | 2006 | en_US |
dc.identifier.other | 25065 | en_US |
dc.identifier.uri | https://dspace.lu.lv/dspace/handle/7/16860 | |
dc.description.abstract | Darba mērķis bija izstrādāt 1-alkil-2-arilmetil-1H-tiēno[2,3-d]-imidazol-5-karbonskābes un to atvasinājumu iegūšanas metodes no 1-alkil-2-arilmetil-4-brom-1H-imidazol-5-karbaldehīdiem. Darbā pētītas šo intermediātu sintēzes iespējas no tādām komerciāli pieejamām izejvielām kā 2,4,5-tribromimidazols un arilacetonitrila atvasinājumi. Sekmīgi veiktas sintezēto 1-alkil-2-arilmetil-4-brom-1H-imidazol-5-karbaldehīdu sametināšanas reakcijas ar 2-merkaptoacetamīdu un etil-2-merkaptoacetātu, un tālāka iegūto sametināšanas produktu ciklizācija par attiecīgajiem 1-alkil-2-arilmetil-1H-tiēno[2,3-d]-imidazol-5-karbonskābes atvasinājumiem, izmantojot gan parasto sildīšanu, gan mikroviļņu tehnoloģiju. | en_US |
dc.description.abstract | The aim of the present work was to elaborate methods of the preparation of 1-alkyl-2-arylmethyl-1H-thieno[2,3-d]-imidazole-5-carboxylic acids and their derivatives from 1-alkyl-2-arylmethyl-4-bromo-1H-imidazole-5-carbaldehydes. The possibilities of synthesis of these intermediates from such commercially available starting materials as 2,4,5-tribromoimidazole and arylacetonitrile derivatives were studied. Successful experiments of the coupling reaction of prepared 1-alkyl-2-arylmethyl-4-bromo-1H-imidazole-5-carbaldehydes with 2-mercaptoacetamide and ethyl 2-mercaptoacetate followed by the cyclization of the obtained coupling products into the corresponding derivatives of 1-alkyl-2-arylmethyl-1H-thieno[2,3-d]-imidazole-5-carboxylic acids both by routine heating and microwave technique were performed. | en_US |
dc.language.iso | N/A | en_US |
dc.publisher | Latvijas Universitāte | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ķīmija | en_US |
dc.title | Imidazola ciklu saturošu termošoka proteīna Hsp90 inhibitoru sintēzes pētījumi | en_US |
dc.title.alternative | Investigation of the Synthesis of Imidazole Containing Thermal Shock Protein Hsp90 Inhibitors | en_US |
dc.type | info:eu-repo/semantics/masterThesis | en_US |