| dc.contributor.advisor | Mandrika, Ilona | en_US |
| dc.contributor.author | Radziņa, Andra | en_US |
| dc.contributor.other | Latvijas Universitāte. Bioloģijas fakultāte | en_US |
| dc.date.accessioned | 2015-03-24T07:59:30Z | |
| dc.date.available | 2015-03-24T07:59:30Z | |
| dc.date.issued | 2013 | en_US |
| dc.identifier.other | 33874 | en_US |
| dc.identifier.uri | https://dspace.lu.lv/dspace/handle/7/20955 | |
| dc.description.abstract | Aptaukošanās un ar to saistītās slimības pēdējā laikā ir pieaugoša problēma Rietumvalstīs, tādēļ plaši tiek pētīti procesi taukaudos. Darba mērķis bija noskaidrot hidroksikarbonskābes (HCA) receptoru ligandu ietekmi uz adipoģenēzi un iekaisuma procesiem, kā arī to ietekmi uz HCA receptoru gēnu ekspresiju cilvēka adipocītos un makrofāgos.
Rezultāti liecina, ka neviens no HCA1-3 receptoru ligandiem neietekmē ne adipoģenēzei raksturīgo transkripcijas faktoru, ne pašu HCA receptoru gēnu ekspresiju SGBS adipocītos un diferencētās adipozo audu cilmes šūnās.
Savukārt HCA2 un HCA3 receptoru ligandi samazina LPS paaugstināto iekaisuma citokīnu gēnu ekspresiju SGBS adipocītos un THP-1 makrofāgos. | en_US |
| dc.description.abstract | Obesity is an increasing problem in Western world and it is associated with many health problems, therefore processes in the adipose tissue are widely investigated. The aim of the present work was to determine the effect of hydroxycarboxylic acid receptor (HCA) ligands on adipogenesis and inflammatory responses as well as their effect on HCA receptor gene expression in human adipocytes and macrophages.
The results show that none of the HCA1-3 receptor ligands has an effect on the gene expression of adipogenic transcription factors or the gene expression of HCA receptors in SGBS adipocytes and differentiated adipose tissue stem cells.
HCA2 and HCA3 receptor ligands decrease LPS stimulated proinflammatory cytokines gene expression in SGBS adipocytes and THP-1 macrophages. | en_US |
| dc.language.iso | N/A | en_US |
| dc.publisher | Latvijas Universitāte | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Bioloģija | en_US |
| dc.title | Hidroksikarbonskābes receptoru (HCAR) ligandu ietekme uz adipoģenēzi un iekaisuma procesiem cilvēka adipocītos un makrofāgos | en_US |
| dc.title.alternative | The effect of hydroxycarboxylic acid receptors (HCAR) ligands on adipogenesis and inflammatory responses in human adipocytes and macrophages | en_US |
| dc.type | info:eu-repo/semantics/bachelorThesis | en_US |
