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Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments

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Автор
Ranka, Renate
Petrovskis, Ivars
Sominskaya, Irina
Bogans, Janis
Bruvere, Ruta
Akopjana, Inara
Ose, Velta
Timofejeva, Irena
Brangulis, Kalvis
Pumpens, Pauls
Baumanis, Viesturs
Дата
2013-01
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Аннотации
Virus-like particles (VLPs) are created by the self-assembly of multiple copies of envelope and/or capsid proteins from many viruses, mimicking the conformation of a native virus. Such noninfectious nanostructures are mainly used as antigen-presenting platforms, especially in vaccine research; however, some of them recently were used as scaffolds in biotechnology to produce targeted nanoparticles for intracellular delivery. This study demonstrates the creation of fusion VLPs using hepatitis B core protein-based system maintaining a fibronectin-binding property from B. burgdorferi BBK32 protein, including the evidence of particles’ transmission to BHK-21 target cells via caveolae/rafts endocythosis. These results make this construct to be an attractive model in development of HBc-based nanoparticles for cellular targeting applications and highlights the fragment of B. burgdorferi BBK32 as a novel cellular uptake-promoting peptide.
URI
http://www.sciencedirect.com/science/article/pii/S1549963412001839
https://dspace.lu.lv/dspace/handle/7/31258
DOI
10.1016/j.nano.2012.05.003
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  • Raksti (MDZF) / Articles [49]
  • Bioloģija, vides un rūpnieciskā biotehnoloģijas/Biological sciences, Environmental and Industrial biotechnology [13]

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