Furazidīna solvātu veidošanās, struktūra un desolvatācija
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Latvijas Universitāte
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Abstract
Darbā ir apkopota informācija par cietvielu kristāliskajam formām un to pētīšanas metodēm; furazidīnu ¬un tā polimorfiem un pseidopolimorfiem. Iegūtas furazidīna pseidopolimorfās formas un jauktie solvāti – dimetilformamīda, dimetilsulfoksīda, dimetilformamīda:ūdens un tetrahidrofurāna:ūdens solvātī. Aprēķinātas jaukto solvātu mijiedarbību enerģijas un pētīts to desolvatācijas mehānisms.
Summarized information about solid phase crystalline forms and their research methods; furazidin polymorphs and its pseidopolymorphs. Furazidin solvates and hybrid solvates were obtained – dimethylformamide, dimethylsulfoxide, dimethylformamide:water, tetrahydrofuran:water. Interaction energy for hybrid solvates were calculated and desolvatation mechanism research.
Summarized information about solid phase crystalline forms and their research methods; furazidin polymorphs and its pseidopolymorphs. Furazidin solvates and hybrid solvates were obtained – dimethylformamide, dimethylsulfoxide, dimethylformamide:water, tetrahydrofuran:water. Interaction energy for hybrid solvates were calculated and desolvatation mechanism research.