Ftorafūra polimorfos formu kristalizācija un fāžu pārejas
Loading...
Date
Authors
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Language
N/A
Abstract
Darbā apskatīta daļiņu izmēra un gaisa relatīvā mitruma ietekme uz ftorafūra α- un β- fāžu pārejas kinētiku dažādās temperatūrās. Ftorafūra α- un β- kristālisko modifikāciju maisījumos abu formu saturu noteica, veicot pilna profila analīzi. Noteikta ftorafūra α- un β- līdzsvara temperatūra, izmantojot karsēšanas metodi un šķīšanas metodi, kā arī α- un γ- formu līdzsvara temperatūras, izmantojot karsēšanas metodi. Izmantojot noteiktās līdzsvara un kušanas temperatūras, aprēķināta ftorafūra β- un γ- formu līdzsvara temperatūra. Noteikti optimāli apstākļi ftorafūra ε- formas kristalizācijai no spirtu šķīdumiem.
The impact of particle size and air relative humidity on tegafur α- and β- form phase transition kinetics at various temperatures is discussed in this work. The content of both forms of crystalline modifications of tegafur α- and β- polymorph mixture was determined using full profile analysis. The balance temperature of tegafur α- and β- polymorphs was defined using a heating method and solubility method, and the balance temperature of α- and γ- forms was defined using a heating method. The balance temperature of β- and γ- polymorphs was calculated from defined balance temperatures and melting temperatures. Optimal conditions of tegafur ε- form crystallization from alcohols were determined.
The impact of particle size and air relative humidity on tegafur α- and β- form phase transition kinetics at various temperatures is discussed in this work. The content of both forms of crystalline modifications of tegafur α- and β- polymorph mixture was determined using full profile analysis. The balance temperature of tegafur α- and β- polymorphs was defined using a heating method and solubility method, and the balance temperature of α- and γ- forms was defined using a heating method. The balance temperature of β- and γ- polymorphs was calculated from defined balance temperatures and melting temperatures. Optimal conditions of tegafur ε- form crystallization from alcohols were determined.