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  • B4 – LU fakultātes / Faculties of the UL
  • A -- Medicīnas un dzīvības zinātņu fakultāte / Faculty of Medicine and Life Sciences
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Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats 

Beitnere, Ulrika; Dzirkale, Zane; Isajevs, Sergejs; Rumaks, Juris; Svirskis, Simons; Klusa, Vija (Elsevier, 2014)
The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic ...
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γ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze test in mice 

Jansone, Baiba; Rumaks, Juris; Dzirkale, Zane; Pupure, Jolanta; Svirskis, Šimons; Muceniece, Ruta; Klusa, Vija (Elsevier, 2009)
Little is known about the endogenous functions of γ1- and γ2-melanocyte stimulating hormones (γ1- and γ2-MSH). Although γ-MSHs bind to melanocortin receptor subtypes 3 and 4, we have previously shown that these peptides ...
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Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease 

Pilipenko, Vladimirs; Narbute, Karina; Beitnere, Ulrika; Rumaks, Juris; Pupure, Jolanta; Jansone, Baiba; Klusa, Vija (Elsevier, 2018-01-05)
Recent studies devoted to neuroprotection have focused on the role of the gamma-aminobutyric acid (GABA) system in regulating neuroinflammatory processes which play a key role in the neurodegenerative processes observed ...
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Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system 

Dzirkale, Zane; Rumaks, Juris; Svirskis, Simons; Mazina, Olga; Allikalt, Anni; Rinken, Ago; Jekabsons, Kaspars; Muceniece, Ruta; Klusa, Vija (Elsevier, 2013)
The present study for the first time is devoted to identify central effects of synthetic lunasin, a 43 amino acid peptide. A markedly expressed neuroleptic/cataleptic effect was observed at low (0.1–10 nmol/mouse) centrally ...

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AuthorKlusa, Vija (4)
Rumaks, Juris (4)
Dzirkale, Zane (3)Beitnere, Ulrika (2)Jansone, Baiba (2)Muceniece, Ruta (2)Pupure, Jolanta (2)Svirskis, Simons (2)Allikalt, Anni (1)Isajevs, Sergejs (1)... View MoreSubjectMEDICINE (3)Memory (2)Anxiety (1)Baclofen (1)Behaviour (1)cAMP (1)Dopamine receptors (1)Elevated plus-maze test (1)Ethanol withdrawal responses (1)Haloperidol (1)... View MoreDate Issued2018 (1)2014 (1)2013 (1)2009 (1)

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