Malonskābju atvasinājumu elektroķīmiska dekarboksilēšana – jaunu C–N un C–F saišu veidošana
Loading...
Date
Authors
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Latvijas Universitāte
Language
lav
Abstract
Maģistra darba ietvaros tika sintezēti slāpekļa nukleofilus saturoši N-acetilaminomalonskābes monoesteri, kas pēc tam tika izmantoti pirolidīnu elektroķīmiskai sintēzei iekšmolekulārā Hofer-Moest reakcijā. Tika pārbaudīta elektroķīmiski iegūto pirolidīnu reaģētspēja. Papildus tika veikta arī a-fluormalonskābju monoesteru sintēze, elektroķīmiskās fluordekarboksilēšanas reakcijas apstākļu optimizēšana un elektrodu virsmas pētīšana.
In this master’s thesis, tethered nitrogen nucleophile-containing N-acetylamino malonic acid monoesters were synthesised and used for the electrochemical synthesis of pyrrolidines via an intramolecular Hofer-Moest reaction. The reactivity of the synthesised pyrrolidines was investigated. Additionally, the thesis involves the synthesis of a-fluoromalonic acid monoesters, the optimization electrochemical fluorodecarboxylation reactions conditions, and electrode surface studies.
In this master’s thesis, tethered nitrogen nucleophile-containing N-acetylamino malonic acid monoesters were synthesised and used for the electrochemical synthesis of pyrrolidines via an intramolecular Hofer-Moest reaction. The reactivity of the synthesised pyrrolidines was investigated. Additionally, the thesis involves the synthesis of a-fluoromalonic acid monoesters, the optimization electrochemical fluorodecarboxylation reactions conditions, and electrode surface studies.