Lapatiniba protolītisko īpašību izpēte un sāļu iegūšana
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Latvijas Universitāte
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lav
Abstract
Maģistra darba ietvaros veikta lapatiniba potenciometriskā titrēšana neūdens vidē, izmantojot divas šķīdinātāju sistēmas: N,N-dimetilformamīda un ūdens maisījums; metanola, acetonitrila, 1,4 dioksāna un ūdens maisījums. Protonēšanās konstante ūdens vidē noteikta, izmantojot Yasuda Shedlovsky ekstrapolāciju. Veikta lapatiniba sāļu sintēze, izmantojot sālsskābi, p-toluolsulfonskābi, citronskābi, maleīnskābi, vīnskābi, skābeņskābi. Iegūtie produkti analizēti, izmantojot pulvera rentgendifraktometriju, diferenciāli termisko analīzi un kodolmagnētiskās rezonanses spektroskopiju. Atsevišķiem paraugiem pārbaudīta stabilitāte paaugstināta gaisa relatīvā mitruma apstākļos.
In this master's thesis lapatinib potentiometric titration were performed in non-aqueous medium using two solvent systems: N,N-dimethylformamide and water mixture; methanol, acetonitrile, 1,4 dioxane and water. Protonation constant in the water was determined using Yasuda-Shedlovsky extrapolation. Lapatinib salts were synthesized using hydrochloric acid, p-toluenesulfonic acid, citric acid, maleic acid, L-tartaric acid, oxalic acid. The resulting products were analyzed using powder X-ray diffraction, differential thermal analysis and nuclear magnetic resonance spectroscopy. Individual samples were tested for stability in high humidity.
In this master's thesis lapatinib potentiometric titration were performed in non-aqueous medium using two solvent systems: N,N-dimethylformamide and water mixture; methanol, acetonitrile, 1,4 dioxane and water. Protonation constant in the water was determined using Yasuda-Shedlovsky extrapolation. Lapatinib salts were synthesized using hydrochloric acid, p-toluenesulfonic acid, citric acid, maleic acid, L-tartaric acid, oxalic acid. The resulting products were analyzed using powder X-ray diffraction, differential thermal analysis and nuclear magnetic resonance spectroscopy. Individual samples were tested for stability in high humidity.