Kontakta un bezkontakta difūzās refleksijas spektrometrija ādas patoloģiju novērtējumam
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Latvijas Universitāte
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Kontakta un bezkontakta difūzās refleksijas spektrometrija ādas patoloģiju novērtējumam
Anotācija
Darbā veikti ādas asinsvadu un pigmentētu veidojumu pētījumi ar kontakta un bezkontakta difūzās atstarošanas metodi. Pilnveidotas un aprobētas klīniskajos mērījumos divas ādas in vivo neinvazīva novērtējuma metodikas – asinsvadu patoloģiju fototerapijas monitoringa metodika un pigmentēto un asinsvadu patoloģiju diagnostikas metodika. Piedāvāti trīs jauni kritēriji ādas asinsvadu patoloģiju fototerapijas monitoringam. Ādas pigmentēto patoloģiju (t. sk. melanomu) neinvazīvai optiskai diagnostikai papildus spektrālo attēlu analīzei piedāvāta melanīna-hemoglobīna relatīvo koncentrāciju korelāciju analīzes metode. Pierādīts, ka šī metode statistiski pārliecinoši sagrupē melanomas, citus pigmentētus veidojumus un asinsvadu patoloģijas un paver ceļu agrīnai melanomu bezkontakta diagnostikai.
Atslēgvārdi: ādas asinsvadu un pigmentētie veidojumi, in vivo difūzās refleksijas spektrometrija, ādas multispektrālā attēlošana.
Contact and contactless diffuse reflectance spectrometry for assessment of skin pathologies Abstract Studies of vascular and pigmented skin malformations by contact and contactless diffuse reflectance methods have been performed in this work. Two in vivo noninvasive evaluation skin methods have been improved: phototherapy monitoring method of vascular lesions and diagnostic method of vascular and pigmented lesions. Three new criteria have been proposed for phototherapy monitoring of skin vascular malformations. For noninvasive optical diagnostics of pigmented skin lesions (including melanomas) the analysis method of melanin-hemoglobin relative concentrations correlations has been proposed in addition to analysis of spectral images. It was confirmed that these method certainly statistically classify melanomas, other pigmented lesions and vascular lesions and opens up new opportunities for early noncontact diagnostic of melanoma. Keywords: skin vascular and pigmented lesions, in vivo diffuse reflectance spectrometry, skin multispectral imaging.
Contact and contactless diffuse reflectance spectrometry for assessment of skin pathologies Abstract Studies of vascular and pigmented skin malformations by contact and contactless diffuse reflectance methods have been performed in this work. Two in vivo noninvasive evaluation skin methods have been improved: phototherapy monitoring method of vascular lesions and diagnostic method of vascular and pigmented lesions. Three new criteria have been proposed for phototherapy monitoring of skin vascular malformations. For noninvasive optical diagnostics of pigmented skin lesions (including melanomas) the analysis method of melanin-hemoglobin relative concentrations correlations has been proposed in addition to analysis of spectral images. It was confirmed that these method certainly statistically classify melanomas, other pigmented lesions and vascular lesions and opens up new opportunities for early noncontact diagnostic of melanoma. Keywords: skin vascular and pigmented lesions, in vivo diffuse reflectance spectrometry, skin multispectral imaging.