Makrociklisko diazonamīda A analogu sintēze
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Latvijas Universitāte
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lav
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Makrociklisko Diazonamīda A analogu sintēze. Vitkovska V., zinātniskais vadītājs profesors Dr. chem. Sūna E., zinātniskais konsultants Mg. chem. Kalniņš T. Maģistra darbs ir uzrakstīts latviešu valodā, tā apjoms ir 82 lappuses. Darbs satur 69 attēlus, 5 tabulas, 62 literatūras avotus un 1 pielikumu. Darbā sintezēti dabasvielas Diazonamīda A vienkāršoti makrocikliski analogi. Mērķsavienojumu sintēzes atslēgas solim izmantota cikla saslēgšanas metatēze. Iegūtajiem savienojumiem noteikta saistības afinitāte ar tubulīnu un in vitro citotoksicitāte uz vēža šūnu līnijām. DIAZONAMĪDS A, PRETVĒŽA LĪDZEKĻI, MAKROCIKLI, CIKLA SASLĒGŠANAS METATĒZE
Synthesis of macrocyclic analogues of Diazonamide A. Vitkovska V., supervisor prof., Dr. chem. Suna E., consulted MSc. chem. Kalnins T. Master thesis is written in Latvian and consists of 82 pages, 69 figures, 5 tables, 62 literature references and 1 appendice. Simplified macrocyclic analogues of natural compound Diazonamide A were synthesized. Synthetic route contains ring closing metathesis as the key step. Binding affinity with tubulin and in vitro citotoxicity against cancer cell lines were measured. DIAZONAMIDE A, ANTICANCER AGENTS, MACROCYCLES, RING CLOSING METATHESIS
Synthesis of macrocyclic analogues of Diazonamide A. Vitkovska V., supervisor prof., Dr. chem. Suna E., consulted MSc. chem. Kalnins T. Master thesis is written in Latvian and consists of 82 pages, 69 figures, 5 tables, 62 literature references and 1 appendice. Simplified macrocyclic analogues of natural compound Diazonamide A were synthesized. Synthetic route contains ring closing metathesis as the key step. Binding affinity with tubulin and in vitro citotoxicity against cancer cell lines were measured. DIAZONAMIDE A, ANTICANCER AGENTS, MACROCYCLES, RING CLOSING METATHESIS