Pirmreizēji diagnosticēta hroniska C vīrushepatīta morfoloģiskais un klīniskais raksturojums
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Latvijas Universitāte
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lav
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245 pacienti bija vīrieši un 226 bija sievietes vecumā no 18 – 73 gadiem, vidējais vecums – 42,31 gadi (SD±11,243). 51% pacientu (n=240) tika konstatēta Ishak 1. stadija. 18% (n=85) tika konstatēta 2. Ishak stadija, 13% (n=63) 0. stadija, 10% (n=47) 3. Ishak stadija, 4% (n=18) 5. Ishak stadija, 3% (n=12) 4. Ishak stadija un 1% (n=6) pacientu konstatēta 6. Ishak stadija - ciroze. Hepatīta aktivitātes indekss (HAI) visbiežāk - 46% (n=216) noteikts robežās no 6-8 punktiem. 26% un 25% (n=125 un n=117) pacientu HAI attiecīgi robežās no 0-2 un 3-5 punktiem. 381 pacients kopumā norādījis 572 iespējamos inficēšanās ceļus. 46% atzīmēja, ka ir veiktas medicīniskas manipulācijas, 18% (n=102) veikti tetovējumi vai pīrsingi, 10% (n=57) atzīmēta intravenozo narkotiku lietošana, stomatologa pakalpojumus kā vienīgo iespējamo inficēšanās ceļu atzīmēja 8% pacientu (n=44). 1. genotips konstetēts 60% gadījumu (n=137), 2% (n=4) noteikts 2. genotips, 36% (n=83) 3. genotips, 1b. un 2. genotipa kombinācija noteikta 2% (n=4). 2 Secinājumi. 51% pacientu (n=240) tika konstatēta Ishak 1. stadija, 18% (n=85) tika konstatēta 2. Ishak stadija un 1% (n=6) pacientu 6. Ishak stadija - ciroze. Hepatīta aktivitātes indekss (HAI) visbiežāk - 46% (n=216) tika konstatēts robežās no 6-8 punktiem. 88% pacientu (n=415) sūdzību par savu veselības stāvokli netika konstatētas, 12% (n=55) bija vsmaz viena sūdzībaKā biežākais pieminēts diskomforts labajā paribē 38% (n=24), 30% (n=19) pacientu sūdzējas par nespēku, 19% (n=12) par sāpēm mugurā, 5% (n=3) par meteorismu un 5% par samazinātu apetīti, un 3% (n=2) par sliktu dūšu. 381 pacients kopumā norādījis 572 iespējamos inficēšanās ceļus. 46% atzīmēja, ka ir veiktas medicīniskas manipulācijas, 18% (n=102) veikti tetovējumi vai pīrsingi, 10% (n=57) atzīmēta intravenozo narkotiku lietošana, stomatologa pakalpojumus kā vienīgo iespējamo inficēšanās ceļu atzīmēja 8% pacientu (n=44). 1. genotips konstetēts 60% gadījumu (n=137), 2% (n=4) noteikts 2. genotips, 36% (n=83) 3. genotips, 1b. un 2. genotipa kombinācija noteikta 2% (n=4).
245 patients were men and 226 were women aged 18-73 years, mean age - 42.31 years (SD ± 11.243). 51% of patients (n = 240) showed Ishak stage 1. 18% (n = 85) showed Ishak stage 2, 13% (n = 63) Ishak stage 0, 10% (n = 47) Ishak stage 3, 4% (n = 18) Ishak stage 5, 3% (n = 12) Ishak stage 4 and 1% (n = 6) patients showed Ishak stage 6 - cirrhosis. Hepatitis Activity Index (HAI) for most patients 46% (n = 216) was between 6-8 points. 26% and 25% (n=125 and n=117) of patients had the range of HAI 0-2 and 3-5 points respectively. The average count of blood platelets set 223 570 (SD ± 61.165), alanine aminotransferase (ALT) 92,31 (SD ± 70.232) (U/L) and asparataminotransferase (AST) 64,13 (SD ± 62.089) (U/L). Statistically significant negative correlation (p <0.01; Pearson correlation coefficient) between Ishak fibrosis stage, and the average number of platelets was found. 88% of patients (n = 415) dont have any complains about their medical condition and only in 12% (n = 55) of patients had at least one complain. The most frequent complication was discomfort on the right side of ribs 38% (n = 24), 30% (n = 19) patients complained about fatigue, 19% (n = 12) had backache, 5% (n = 3) flatulence and 5% reduced appetite, and 3% (n = 2) nausea. There were no statistically significant difference comparing patients with and without complaints, and the average degree of Ishak fibrosis (p> 0.05; the average value of t-test). 381 patient generally indicated 572 potential routes of infection. 46% noted that it could be carried out medical procedures, 18% (n = 102) made tattoos or piercings, 10% (n = 57) marked intravenous drug use, dental care as the only possible of contamination noted in 8% of patients (n = 44). Genotype 1 was found in 60% (n = 137) patients, in 2% (n = 4) genotype 2, in 36% (n = 83) genotype 3. Genotype 1b and 2 combination in 2% (n = 4).
245 patients were men and 226 were women aged 18-73 years, mean age - 42.31 years (SD ± 11.243). 51% of patients (n = 240) showed Ishak stage 1. 18% (n = 85) showed Ishak stage 2, 13% (n = 63) Ishak stage 0, 10% (n = 47) Ishak stage 3, 4% (n = 18) Ishak stage 5, 3% (n = 12) Ishak stage 4 and 1% (n = 6) patients showed Ishak stage 6 - cirrhosis. Hepatitis Activity Index (HAI) for most patients 46% (n = 216) was between 6-8 points. 26% and 25% (n=125 and n=117) of patients had the range of HAI 0-2 and 3-5 points respectively. The average count of blood platelets set 223 570 (SD ± 61.165), alanine aminotransferase (ALT) 92,31 (SD ± 70.232) (U/L) and asparataminotransferase (AST) 64,13 (SD ± 62.089) (U/L). Statistically significant negative correlation (p <0.01; Pearson correlation coefficient) between Ishak fibrosis stage, and the average number of platelets was found. 88% of patients (n = 415) dont have any complains about their medical condition and only in 12% (n = 55) of patients had at least one complain. The most frequent complication was discomfort on the right side of ribs 38% (n = 24), 30% (n = 19) patients complained about fatigue, 19% (n = 12) had backache, 5% (n = 3) flatulence and 5% reduced appetite, and 3% (n = 2) nausea. There were no statistically significant difference comparing patients with and without complaints, and the average degree of Ishak fibrosis (p> 0.05; the average value of t-test). 381 patient generally indicated 572 potential routes of infection. 46% noted that it could be carried out medical procedures, 18% (n = 102) made tattoos or piercings, 10% (n = 57) marked intravenous drug use, dental care as the only possible of contamination noted in 8% of patients (n = 44). Genotype 1 was found in 60% (n = 137) patients, in 2% (n = 4) genotype 2, in 36% (n = 83) genotype 3. Genotype 1b and 2 combination in 2% (n = 4).