Potenciālu IRE1a inhibitoru sintēze
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Latvijas Universitāte
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lav
Abstract
Bakalaura darba ietvaros tika sintezēti aizvietoti 1H-1,2,4-triazol-5-amīni, kā arī oksazolamīni un pirazolamīni, kas varētu būt potenciāli IRE1α inhibitori. Tika pētīta 1H-1,2,4-triazol-5-amīnu acilēšana un endocikliski acilēto savienojumu izomerizācija par eksocikliski acilētiem savienojumiem.
Bachelor’s thesis is dedicated to the synthesis of substituted 1H-1,2,4-triazol-5-amines as well as substituted oxazolamines and pyrazolamines, that could be potential inhibitors of IRE1α. Acylation of 1H-1,2,4-triazol-5-amines and endocyclically acylated compound isomerization into exocyclically acylated compounds was investigated.
Bachelor’s thesis is dedicated to the synthesis of substituted 1H-1,2,4-triazol-5-amines as well as substituted oxazolamines and pyrazolamines, that could be potential inhibitors of IRE1α. Acylation of 1H-1,2,4-triazol-5-amines and endocyclically acylated compound isomerization into exocyclically acylated compounds was investigated.