Browsing Publicēti raksti (MF) / Published Articles by Author "Dzirkale, Zane"
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Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats
Beitnere, Ulrika; Dzirkale, Zane; Isajevs, Sergejs; Rumaks, Juris; Svirskis, Simons; Klusa, Vija (Elsevier, 2014)The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic ... -
Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats
Narbute, Karīna; Piļipenko, Vladimirs; Pupure, Jolanta; Dzirkale, Zane; Jonavičė, Ugnė; Tunaitis, Virginijus; Kriaučiūnaitė, Karolina; Jarmalavičiūtė, Akvilė; Jansone, Baiba; Kluša, Vija; Pivoriūnas, Augustas (AlphaMed Press Wiley, 2019-04-22)Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression ... -
Lunasin-induced behavioural effects in mice: Focus on the dopaminergic system
Dzirkale, Zane; Rumaks, Juris; Svirskis, Simons; Mazina, Olga; Allikalt, Anni; Rinken, Ago; Jekabsons, Kaspars; Muceniece, Ruta; Klusa, Vija (Elsevier, 2013)The present study for the first time is devoted to identify central effects of synthetic lunasin, a 43 amino acid peptide. A markedly expressed neuroleptic/cataleptic effect was observed at low (0.1–10 nmol/mouse) centrally ... -
γ1- and γ2-melanocyte stimulating hormones induce central anxiogenic effects and potentiate ethanol withdrawal responses in the elevated plus-maze test in mice
Jansone, Baiba; Rumaks, Juris; Dzirkale, Zane; Pupure, Jolanta; Svirskis, Šimons; Muceniece, Ruta; Klusa, Vija (Elsevier, 2009)Little is known about the endogenous functions of γ1- and γ2-melanocyte stimulating hormones (γ1- and γ2-MSH). Although γ-MSHs bind to melanocortin receptor subtypes 3 and 4, we have previously shown that these peptides ...