| dc.contributor.advisor | Plotniece, Aiva | en_US |
| dc.contributor.author | Rakitskis, Aleksandrs | en_US |
| dc.contributor.other | Latvijas Universitāte. Medicīnas fakultāte | en_US |
| dc.date.accessioned | 2015-03-24T07:38:36Z | |
| dc.date.available | 2015-03-24T07:38:36Z | |
| dc.date.issued | 2010 | en_US |
| dc.identifier.other | 16675 | en_US |
| dc.identifier.uri | https://dspace.lu.lv/dspace/handle/7/20360 | |
| dc.description.abstract | Darbā dotas 1,4-dihidropiridīna (1,4-DHP) atvasinājumu modifikācijas, lai veidotu dabas lipīdiem tuvākas struktūras. Iegūti savienojumi, kas 1,4-DHP cikla 3,5-vietās satur lipīdu veida aizvietotājus un 2,6-vietās katjonus piridīna atvasinājumus. Savienojumi sintezēti kā potenciālie gēnu transfekcijas aģenti turpmākiem struktūras-aktivitātes pētījumiem. Dots savienojumu fizikāli-ķīmiskais raksturojums. | en_US |
| dc.description.abstract | In this work, modifications of 1,4-dihydropyridine (1,4-DHP) derivatives to lipide-like structures are presented. The compounds that contain lipide-like substituents at the positions 3- and 5- and cationic pyridine derivatives at the positions 2- and 6- of the 1,4-DHP nucleus have been obtained. The compounds have been synthesised as potential agents of gene transfection for establishment of structure activity relationships. Physically-chemical characteristics of the synthesised compounds are also given. | en_US |
| dc.language.iso | N/A | en_US |
| dc.publisher | Latvijas Universitāte | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Farmācija | en_US |
| dc.title | Glicerolipīdu fragmentus saturošu 1,4-dihidropiridīna atvasinājumu kā potenciālo transportmolekulu sintēze un īpašību pētījumi | en_US |
| dc.title.alternative | Synthesis and properties of glycerolipid fragments containing 1,4-dihydropyridine derivatives as potential transportmolecules | en_US |
| dc.type | info:eu-repo/semantics/masterThesis | en_US |
