Tetrazīna ciklu saturoši proteīnu linkeri

Abstract

Proteīnu linkeri. Augšpuls H., zinātniskais vadītājs doc. Kļimenkovs I., bakalaura darbs, 3 lappuses, 27 attēli, 27 literatūras avoti, 2 pielikumi. Latviešu valodā. PROTEĪNU LINKERI, GABRIELA METODE, AZĪDI, AIZSARGGRUPAS, AMĪDU SINTĒZE Bakalura darba ietvaros veikta proteīnu linkera sintēze ar aizsargātu aldehīdgrupu. No 1,8-dibromoktāna sintezēts oktān-1,8-diamīns, kam viena aminogrupa aizsargāta ar Boc-grupu. Aizsargātais diamīns acilēts ar (4-azidofenil)etiķskābi, kas iegūta no (4-aminofenil)etiķskābes. No acilētā produkta ieguva triazolu, no kura tālāk tika iegūts aizsargātais tetrazīna ciklu saturošais proteīnu linkeris.

Protein linkers. Augšpuls H., supervisor Doc. Kļimenkovs I. Course thesis, 32 pages, 27 figures, 27 literature references, 2 appendices. In Latvian. PROTEIN LINKERS, GABRIEL METHOD, AZIDES, PROTECTING GROUPS, AMIDE SYNTHESIS Within the framework of this thesis, synthesis of a protein linker with a protected aldehyde group has been accomplished. Octane-1,8-diamine has been prepared from 1,8-dibromooctane. One of the two aminogroups has been protected by Boc-group. The protected diamine has been acylated by (4-azidophenyl)acetic acid, prepared from (4-aminophenyl)acetic acid. From the acylated product triazole was synthesised, from wich the protected tetrazine ring containing protein linker was obtained.