Potenciālu IRE1a inhibitoru sintēze

dc.contributor.advisor	Kļimenkovs, Igors
dc.contributor.author	Šadauskis, Jānis
dc.contributor.other	Latvijas Universitāte. Ķīmijas fakultāte
dc.date.accessioned	2023-09-06T01:03:17Z
dc.date.available	2023-09-06T01:03:17Z
dc.date.issued	2023
dc.identifier.other	96515
dc.identifier.uri	https://dspace.lu.lv/dspace/handle/7/64193
dc.description.abstract	Bakalaura darba ietvaros tika sintezēti aizvietoti 1H-1,2,4-triazol-5-amīni, kā arī oksazolamīni un pirazolamīni, kas varētu būt potenciāli IRE1α inhibitori. Tika pētīta 1H-1,2,4-triazol-5-amīnu acilēšana un endocikliski acilēto savienojumu izomerizācija par eksocikliski acilētiem savienojumiem.
dc.description.abstract	Bachelor’s thesis is dedicated to the synthesis of substituted 1H-1,2,4-triazol-5-amines as well as substituted oxazolamines and pyrazolamines, that could be potential inhibitors of IRE1α. Acylation of 1H-1,2,4-triazol-5-amines and endocyclically acylated compound isomerization into exocyclically acylated compounds was investigated.
dc.language.iso	lav
dc.publisher	Latvijas Universitāte
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Ķīmija
dc.subject	IRE1a
dc.subject	IRE1a INHIBITORI
dc.subject	1,2,4-TRIAZOL-5-AMĪNU ACILĒŠANA
dc.subject	OKSAZOLAMĪNI
dc.subject	PIRAZOLAMĪNI
dc.title	Potenciālu IRE1a inhibitoru sintēze
dc.title.alternative	Synthesis of potencial IRE1a inhibitors
dc.type	info:eu-repo/semantics/bachelorThesis